SIRT5 promotes arterial thrombosis by modulating fibrinolysis through endothelial PAI-1 expression

Recently published findings by Liberale and colleagues suggest a novel role for Sirtuin 5 in arterial thrombosis by regulating fibrinolysis through plasminogen activator inhibitor 1 (PAI-1). These results shed new light onto the pathophysiology of arterial thrombus formation which underlies the majority of acute atherosclerotic complications. Also, they affirm the intrinsic relationship between lifespan regulating genes, vascular dysfunction and age-related cardiovascular disease, thus indicating these genes' potential as novel targets for the prevention and therapy of cardiovascular afflictions. Future studies should assess the predictive ability of SIRT5 in patients with acute cardiovascular or cerebrovascular events. Also, the design of specific SIRT5 inhibitors will allow trials aiming at investigating the efficacy of SIRT5 blockage in the clinical setting.