Biomarkers for predicting cardiac magnetic resonance parameters in myocardial infarction
In a recent substudy of the CLEVER-ACS trial, investigators from the CMC and collaborating centers examined whether established and emerging biomarkers measured at baseline are associated with cardiac MRI findings 30 days after ST-segment elevation myocardial infarction.
Among 56 patients, high-sensitivity troponin T (hsTnT) and N-terminal pro–B-type natriuretic peptide (NT-proBNP) showed strong and consistent associations with key MRI-derived measures, including cardiac function, infarct size, and microvascular injury. In contrast, the novel biomarkers cellular communication network factor 1 (CCN1) and proprotein convertase subtilisin/kexin type 9 (PCSK9) showed limited or no additional value.
Overall, established biomarkers (hsTnT and NT-proBNP) remain highly informative for characterizing intermediate post-infarction cardiac injury, whereas newer candidates did not improve discrimination in this setting.
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