Cardiovascular (CV) and cerebrovascular diseases, the leading causes of death and disability worldwide, are driven by both the aging process and inflammation. Indeed, the concept of inflamm-aging recognizes that low-grade inflammatory pathways observed in the elderly contribute to CV risk. Understanding the mechanisms that link inflammation and aging could reveal new therapeutic targets and offer options to cope with the growing aging population worldwide. In this outstanding article Liberale and colleagues review recent scientific advances in the pathways through which inflamm-aging mediates age-dependent decline in CV function and disease onset; eventually he translational potential of such concepts into everyday clinical practice is discussed. Check out the full article, now available at www.jacc.org.