Vascular (dys)function in the failing heart
Coronary and systemic vascular dysfunction play a key role in the onset and progression of heart failure (HF), regardless of whether ejection fraction is reduced. Gaining insight into functional changes across different vascular segments—from the aorta to the capillaries—helps reveal the underlying mechanisms of disease development and informs potential therapeutic approaches. In a recent review article, Prof. Luca Liberale and colleagues present a mechanistic overview of vascular dysfunction in the pathogenesis of HF with or without reduced ejection fraction, emphasizing the need for integrated treatment strategies that account for vascular health in the management of various HF phenotypes.
Florian Wenzl