Towards personalized antithrombotic management

TFL - antithrombotic management

Haemostasis was essential for survival throughout evolution. Indeed, for hunters and gatherers, the probability of dying from bleeding after injury was much higher than dying of a heart attack or stroke. On the other hand, inherited or acquired von Willebrand disease is associated with nose bleedings, easy bruising, menometrorrhagias and excessive blood loss during and after interventions. Hence, there is a sweet spot at which both cardiovascular disorders and major bleedings are unlikely to occur. A personalized approach would minimize both thrombus formation and bleeding. Check out this  State of the Art Review by Thomas F. Lüscher and colleagues published in the European Heart Journal, in which the differential and personalized use of anticoagulants, platelet inhibitors, and devices is comprehensively reviewed.